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Inside our examine, we had been in a position to drastically escalate the dose of CX-5461 past that achieved in the very first-in-human analyze in clients with hematologic cancers. The RP2D of 475 mg/m2 on days one, 8, and fifteen of a 4-7 days cycle, was dependant on phototoxicity, which occurred In spite of stringent UV light-weight avoidance p